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UGID:157115     UniGene Hs.166486     Homo sapiens (human)   CLCN5
Chloride channel, voltage-sensitive 5 (CLCN5)

Human protein-coding gene CLCN5. Represented by 206 ESTs from 99 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 157115 - Hs.166486]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001121370.1 CLCN5 gene product H. sapiens 100.0 815
XP_001083186.2 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform 4 M. mulatta 99.8 815
XP_003917761.1 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform 1 P. anubis 99.8 815
NP_001230691.1 Clcn5 gene product M. musculus 98.3 815
NP_001080969.1 chloride channel, voltage-sensitive 5 X. laevis 86.5 807
XP_001920783.2 PREDICTED: H(+)/Cl(-) exchange transporter 5-like D. rerio 83.5 810
NP_648834.1 chloride channel-c, isoform B D. melanogaster 66.6 739
NP_495940.1 Protein CLH-5 C. elegans 53.0 731
Other hits (2 of 38) [Show all]SpeciesId(%)Len(aa)
XP_003317509.2 PREDICTED: LOW QUALITY PROTEIN: H(+)/Cl(-) exchange transporter 5 P. troglodytes 99.0 830
XP_549002.3 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform 2 C. lupus familiaris 98.9 808

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: kidney; mixed; embryonic tissue; testis; brain; eye; lung; uncharacterized tissue; placenta; uterus; skin; liver; esophagus; blood; pancreas; pituitary gland; mammary gland; adrenal gland; thymus; intestine; ascites; heart; stomach; muscle; bone; ear; prostate; spleen; lymph node; connective tissue
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: X
Map position: Xp11.23-p11.22
UniSTS entry: Chr X A007H45
UniSTS entry: Chr X A007D27 [Map Viewer]
UniSTS entry: Chr X DXS9840
UniSTS entry: Chr X STS-X81836
UniSTS entry: RH93465
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (16)

BC051691.1 Homo sapiens hypothetical protein LOC158563, mRNA (cDNA clone IMAGE:5314973) A
NM_000084.3 Homo sapiens chloride channel, voltage-sensitive 5 (CLCN5), transcript variant 3, mRNA PA
AK021494.1 Homo sapiens cDNA FLJ11432 fis, clone HEMBA1001099 A
AK025562.1 Homo sapiens cDNA: FLJ21909 fis, clone HEP03834 A
X91906.1 H.sapiens voltage-gated chloride ion channel CLCN5 P
BC130431.1 Homo sapiens chloride channel 5, mRNA (cDNA clone MGC:163303 IMAGE:40146462), complete cds P
BC130429.1 Homo sapiens chloride channel 5, mRNA (cDNA clone MGC:163301 IMAGE:40146460), complete cds P
AK056560.1 Homo sapiens cDNA FLJ31998 fis, clone NT2RP7009322, highly similar to CHLORIDE CHANNEL PROTEIN 5 P
AK290940.1 Homo sapiens cDNA FLJ77943 complete cds, highly similar to Homo sapiens chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) (CLCN5), mRNA P
AK308089.1 Homo sapiens cDNA, FLJ98037 P
NM_001127899.2 Homo sapiens chloride channel, voltage-sensitive 5 (CLCN5), transcript variant 1, mRNA PA
NM_001127898.2 Homo sapiens chloride channel, voltage-sensitive 5 (CLCN5), transcript variant 2, mRNA PA
AK092049.1 Homo sapiens cDNA FLJ34730 fis, clone MESAN2006580, highly similar to Chloride channel protein 5 P
X81836.1 H.sapiens mRNA for Dents Disease candidate gene P
NR_073607.1 Homo sapiens chloride channel, voltage-sensitive 5 (CLCN5), transcript variant 4, non-coding RNA A
NM_001272102.1 Homo sapiens chloride channel, voltage-sensitive 5 (CLCN5), transcript variant 5, mRNA A

EST sequences (10 of 206) [Show all sequences]

AA987680.1 Clone IMAGE:1593386 kidney 3' read A
AA992656.1 Clone IMAGE:1623187 embryonic tissue 3' read
AI016476.1 Clone IMAGE:1623679 embryonic tissue 3' read A
AI042501.1 Clone IMAGE:1660927 mixed 3' read
AI056942.1 Clone IMAGE:1672974 mixed 3' read
AI082873.1 Clone IMAGE:1652906 mixed 3' read A
AI082679.1 Clone IMAGE:1660618 mixed 3' read
CB047546.1 Clone IMAGE:3253358 kidney 5' read
CB047545.1 Clone IMAGE:3253358 kidney 3' read A
BX098173.1 Clone IMAGp998B02215_;_IMAGE:143905 placenta A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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