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UGID:130997     UniGene Hs.1420     Homo sapiens (human)   FGFR3
Fibroblast growth factor receptor 3 (FGFR3)

Human protein-coding gene FGFR3. Represented by 149 ESTs from 70 cDNA libraries. EST representation biased toward blastocyst. Corresponds to 3 reference sequences (different isoforms). [UniGene 130997 - Hs.1420]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_001156685.1 FGFR3 gene product H. sapiens 100.0 807
XP_003310269.1 PREDICTED: fibroblast growth factor receptor 3 isoform 1 P. troglodytes 99.9 807
XP_001101108.1 PREDICTED: fibroblast growth factor receptor 3 isoform 3 M. mulatta 99.9 805
NP_001156687.1 Fgfr3 gene product M. musculus 96.5 799
NP_571681.1 fgfr3 gene product D. rerio 86.5 746
NP_001084170.1 fibroblast growth factor receptor 3 X. laevis 86.3 774
NP_001024723.1 Protein EGL-15, isoform b C. elegans 55.9 315
NP_732286.1 heartless, isoform A D. melanogaster 53.1 450
Other hits (2 of 40) [Show all]SpeciesId(%)Len(aa)
XP_003890956.1 PREDICTED: fibroblast growth factor receptor 3 P. anubis 99.1 781
XP_001488469.3 PREDICTED: fibroblast growth factor receptor 3 E. caballus 97.2 763

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Restricted Expression: blastocyst [show more like this]
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; embryonic tissue; lung; mixed; uncharacterized tissue; skin; kidney; intestine; testis; prostate; eye; stomach; bone marrow; ovary; heart; bladder; connective tissue; placenta; uterus; pancreas; larynx; bone; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4p16.3
UniSTS entry: Chr 4 WI-15208 [Map Viewer]
UniSTS entry: Chr 4 GDB:187013
UniSTS entry: Chr 4 GDB:585477
UniSTS entry: Chr 4 G15851
UniSTS entry: Chr 4 GDB:454675
UniSTS entry: Chr 4 GDB:581559
UniSTS entry: Chr 4 FGFR3
UniSTS entry: Chr 4 GDB:454672
UniSTS entry: Chr 4 RH18137
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (18)

NM_000142.4 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA PA
AF245114.1 Homo sapiens fibroblast growth factor receptor 3 (FGFR3) mRNA, complete cds, alternatively spliced P
M58051.1 Human fibroblast growth factor receptor (FGFR3) mRNA, complete cds P
AF238374.1 Homo sapiens mutant fibroblast growth factor receptor 3 (FGFR3) mRNA, partial cds
AB209441.1 Homo sapiens mRNA for fibroblast growth factor receptor 3 isoform 1 precursor variant protein P
M64347.1 Human novel growth factor receptor mRNA, 3' cds PA
NM_022965.3 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 2, mRNA PA
BC121175.2 Homo sapiens fibroblast growth factor receptor 3, mRNA (cDNA clone IMAGE:40122515), partial cds P
BC128610.1 Homo sapiens fibroblast growth factor receptor 3, mRNA (cDNA clone IMAGE:40122516), partial cds P
BC153824.1 Homo sapiens fibroblast growth factor receptor 3, mRNA (cDNA clone IMAGE:40122517), partial cds P
AK308936.1 Homo sapiens cDNA, FLJ98977 P
AF369213.1 Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds P
AF369212.1 Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds P
AF369211.1 Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds P
X84939.1 H.sapiens mRNA for fibroblast growth factor receptor-3
M59374.1 Human tyrosine kinase (JTK4) mRNA, partial cds
NM_001163213.1 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 3, mRNA PA
HM244683.1 Homo sapiens fibroblast growth factor receptor 3 variant 4 (FGFR3) mRNA, complete cds, alternatively spliced P

EST sequences (10 of 149) [Show all sequences]

AA909405.1 Clone IMAGE:1542686 mixed 3' read A
AI057095.1 Clone IMAGE:1676187 embryonic tissue 3' read A
AI078769.1 Clone IMAGE:1677199 mixed 3' read A
AI219687.1 Clone IMAGE:1841691 mixed 3' read A
AI270451.1 Clone IMAGE:1979142 stomach 3' read A
AI199931.1 Clone IMAGE:1757214 placenta 3' read A
AI343936.1 Clone IMAGE:1925679 intestine 3' read A
AI378807.1 Clone IMAGE:2069667 mixed 3' read A
AI521743.1 Clone IMAGE:2138505 kidney 3' read A
AI624729.1 Clone IMAGE:2236695 uncharacterized tissue 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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