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UGID:150905     UniGene Hs.138499     Homo sapiens (human)   IRAK4
Interleukin-1 receptor-associated kinase 4 (IRAK4)

Human protein-coding gene IRAK4. Represented by 100 ESTs from 79 cDNA libraries. Corresponds to 5 reference sequences (different isoforms). [UniGene 150905 - Hs.138499]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_057207.2 IRAK4 gene product H. sapiens 100.0 459
XP_003906278.1 PREDICTED: interleukin-1 receptor-associated kinase 4 P. anubis 99.8 459
NP_001129573.1 IRAK4 gene product M. mulatta 99.6 459
XP_001166114.1 PREDICTED: interleukin-1 receptor-associated kinase 4 isoform 6 P. troglodytes 99.6 459
NP_084202.2 Irak4 gene product M. musculus 88.7 458
NP_956457.1 irak4 gene product D. rerio 48.4 351
NP_189123.2 protein kinase-like protein A. thaliana 46.1 221
Other hits (2 of 35) [Show all]SpeciesId(%)Len(aa)
XP_543727.1 PREDICTED: interleukin-1 receptor-associated kinase 4 isoform 1 C. lupus familiaris 95.7 459
XP_001488489.1 PREDICTED: interleukin-1 receptor-associated kinase 4 E. caballus 95.4 459

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: blood; mammary gland; eye; bone marrow; brain; vascular; lymph node; intestine; uterus; mixed; uncharacterized tissue; stomach; mouth; muscle; spleen; esophagus; placenta; lung; thymus; skin; testis; kidney; ovary; pancreas; embryonic tissue; parathyroid; liver; trachea; bone
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 12
Map position: 12q12
UniSTS entry: Chr 1 D11S3114
UniSTS entry: Chr 1 D16S325
UniSTS entry: Chr 1 D1S1425
UniSTS entry: Chr 12 RH26210
UniSTS entry: Chr 1 GDB:313261
UniSTS entry: Chr 12 IRAK4__6475
UniSTS entry: Chr 1 D11S2921
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (22)

AY283671.1 Homo sapiens interleukin-1 receptor associated kinase 4 mutant form 2 (IRAK4) mRNA, complete cds P
AY283670.1 Homo sapiens interleukin-1 receptor associated kinase 4 mutant form 1 (IRAK4) mRNA, complete cds P
AK000528.1 Homo sapiens cDNA FLJ20521 fis, clone KAT10395 PA
NM_016123.3 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2, mRNA PA
AY340967.1 Homo sapiens interleukin-1 receptor-associated kinase 4 short form variant 4 (IRAK4) mRNA, complete cds; alternatively spliced P
AY340966.1 Homo sapiens interleukin-1 receptor-associated kinase 4 short form variant 3 (IRAK4) mRNA, complete cds; alternatively spliced P
AY340965.1 Homo sapiens interleukin-1 receptor-associated kinase 4 short form variant 2 (IRAK4) mRNA, complete cds; alternatively spliced P
AY340964.1 Homo sapiens interleukin-1 receptor-associated kinase 4 short form variant 1 (IRAK4) mRNA, complete cds; alternatively spliced P
AY340963.1 Homo sapiens interleukin-1 receptor-associated kinase 4 variant (IRAK4) mRNA, complete cds; alternatively spliced P
AY340962.1 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4) mRNA, complete cds; alternatively spliced P
AF155118.1 Homo sapiens putative protein kinase NY-REN-64 antigen mRNA, complete cds P
AY730682.1 Homo sapiens interleukin-1 receptor associated kinase-4 (IRAK4) mRNA, complete cds P
AK027301.2 Homo sapiens cDNA FLJ14395 fis, clone HEMBA1003250 P
BC013316.1 Homo sapiens interleukin-1 receptor-associated kinase 4, mRNA (cDNA clone MGC:13330 IMAGE:4287014), complete cds PA
AK314288.1 Homo sapiens cDNA, FLJ95044, highly similar to Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), mRNA P
NM_001114182.2 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 1, mRNA PA
AF445802.1 Homo sapiens interleukin-1 receptor associated kinase 4 (IRAK4) mRNA, complete cds P
AK299944.1 Homo sapiens cDNA FLJ50856 complete cds, highly similar to Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) P
AK304583.1 Homo sapiens cDNA FLJ50376 complete cds, highly similar to Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) P
NM_001145258.1 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 5, mRNA PA
NM_001145257.1 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 4, mRNA PA
NM_001145256.1 Homo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 3, mRNA PA

EST sequences (10 of 100) [Show all sequences]

BX105384.1 Clone IMAGp998N15475_;_IMAGE:235214 mixed
BX283594.1 Clone IMAGp958I242016_;_IMAGE:5485535 blood P
CD654941.1 Clone IMAGE:30421550 embryonic tissue 5' read P
AW204470.1 Clone IMAGE:2719434 mixed 3' read A
CF596589.1 Clone IMAGE:30704578 ovary 5' read
AW380440.1 mouth
AW391525.1 stomach
CK000504.1 Clone IMAGE:30708675 mixed 5' read
CD627532.1 uncharacterized tissue P
CD627533.1 uncharacterized tissue P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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