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UGID:150884     UniGene Hs.138211     Homo sapiens (human)   MAPK8
Mitogen-activated protein kinase 8 (MAPK8)

Human protein-coding gene MAPK8. Represented by 124 ESTs from 79 cDNA libraries. Corresponds to 4 reference sequences (different isoforms). [UniGene 150884 - Hs.138211]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
XP_001108815.1 PREDICTED: mitogen-activated protein kinase 8-like isoform 3 M. mulatta 100.0 426
XP_003903688.1 PREDICTED: LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 P. anubis 100.0 426
XP_001136927.1 PREDICTED: mitogen-activated protein kinase 8 isoform 9 P. troglodytes 100.0 426
NP_620637.1 MAPK8 gene product H. sapiens 100.0 426
XP_534943.2 PREDICTED: mitogen-activated protein kinase 8 isoform 1 C. lupus familiaris 100.0 426
XP_001500510.1 PREDICTED: mitogen-activated protein kinase 8 isoform 2 E. caballus 100.0 426
NP_057909.1 Mapk8 gene product M. musculus 100.0 383
NP_446281.1 mitogen-activated protein kinase 8 R. norvegicus 99.8 426
XP_001365893.1 PREDICTED: mitogen-activated protein kinase 8 isoform 2 M. domestica 99.8 426
XP_002186582.1 PREDICTED: mitogen-activated protein kinase 8 isoform 1 T. guttata 99.8 426
XP_001233169.1 PREDICTED: mitogen-activated protein kinase 8 isoform 1 G. gallus 99.8 426
XP_003208054.1 PREDICTED: mitogen-activated protein kinase 8-like isoform 1 M. gallopavo 99.8 426
XP_003359320.1 PREDICTED: mitogen-activated protein kinase 8 S. scrofa 99.8 426
XP_002722717.1 PREDICTED: mitogen-activated protein kinase 8 isoform JNK1 beta2-like isoform 2 O. cuniculus 99.8 426
NP_001080184.1 mitogen-activated protein kinase 8 X. laevis 97.4 425
NP_001103859.1 mapk8a gene product D. rerio 91.3 426
NP_723541.1 basket, isoform B D. melanogaster 87.6 369
NP_741434.2 Protein JNK-1, isoform b C. elegans 82.7 353
NP_563631.2 mitogen-activated protein kinase 11 A. thaliana 48.4 223
NP_013214.1 Hog1p S. cerevisiae 48.1 208
XP_962163.2 mitogen-activated protein kinase sty1 N. crassa 46.8 205
XP_001690852.1 mitogen-activated protein kinase 3 C. reinhardtii 46.3 190
Other hits (2 of 53) [Show all]SpeciesId(%)Len(aa)
XP_003225439.1 PREDICTED: mitogen-activated protein kinase 8-like A. carolinensis 98.7 383
NP_001123415.1 mapk8 gene product X. tropicalis 98.4 369

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; kidney; mixed; mouth; lung; stomach; pancreas; ovary; intestine; embryonic tissue; heart; vascular; uterus; uncharacterized tissue; cervix; mammary gland; blood; trachea; bone; ganglia; connective tissue; skin; spleen; prostate; lymph node
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 10
Map position: 10q11.22
UniSTS entry: Chr 10 MARC_13424-13425:1002294866:1
UniSTS entry: Chr 10 MARC_12374-12375:997362452:1
UniSTS entry: Chr 10 STS-T94087 [Map Viewer]
UniSTS entry: Chr 10 STS-L26318 [Map Viewer]
UniSTS entry: Chr 10 D10S2185
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (18)

L26318.1 Human protein kinase (JNK1) mRNA, complete cds P
NM_002750.2 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1, mRNA P
DQ234352.1 Homo sapiens mitogen-activated protein kinase 8 transcript variant 2 mRNA, complete cds, alternatively spliced P
BC130570.1 Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:163442 IMAGE:40146601), complete cds P
BC130572.1 Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:163444 IMAGE:40146603), complete cds P
AK292523.1 Homo sapiens cDNA FLJ77387 complete cds, highly similar to Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant 4, mRNA P
U34822.1 Human JNK1 alpha2 protein kinase (JNK1A2) mRNA, complete cds P
U35004.1 Human JNK1 beta1 protein kinase (JNK1B1) mRNA, complete cds P
U35005.1 Human JNK1 beta2 protein kinase (JNK1B2) mRNA, complete cds P
NM_139049.1 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2, mRNA P
NM_139047.1 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b2, mRNA P
NM_139046.1 Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1, mRNA P
AK094000.1 Homo sapiens cDNA FLJ36681 fis, clone UTERU2006547
AB451398.1 Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 beta2, partial cds, clone: FLJ08098AAAF P
AB451354.1 Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 alpha1, partial cds, clone: FLJ08021AAAF P
AB451271.1 Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 beta2, complete cds, clone: FLJ08098AAAN P
AB451231.1 Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 alpha1, complete cds, clone: FLJ08021AAAN P
BC144063.1 Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:177600 IMAGE:9052583), complete cds P

EST sequences (10 of 124) [Show all sequences]

AI016505.1 Clone IMAGE:1618340 testis 3' read A
BX100443.1 Clone IMAGp998E055206_;_IMAGE:2110828 mixed
BX116807.1 Clone IMAGp998H195328_;_IMAGE:2157762 mixed
AI274996.1 Clone IMAGE:1877317 mixed 3' read A
T07671.1 Clone HFBEM52 brain
AI418245.1 Clone IMAGE:2110828 mixed 3' read PA
AI307276.1 Clone IMAGE:2054697 kidney 3' read A
AI480307.1 Clone IMAGE:2157762 mixed 3' read P
AI681315.1 Clone IMAGE:2272565 lung 3' read
AI803204.1 Clone IMAGE:2063918 mixed 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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