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UGID:148638     UniGene Hs.130031     Homo sapiens (human)   TRIO
Trio Rho guanine nucleotide exchange factor (TRIO)

Human protein-coding gene TRIO. Represented by 565 ESTs from 241 cDNA libraries. Corresponds to reference sequence NM_007118.2. [UniGene 148638 - Hs.130031]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_009049.2 TRIO gene product H. sapiens 100.0 3096
XP_003899562.1 PREDICTED: LOW QUALITY PROTEIN: triple functional domain protein P. anubis 99.9 3042
XP_002804369.1 PREDICTED: triple functional domain protein-like M. mulatta 99.7 3040
XP_517637.3 PREDICTED: triple functional domain protein P. troglodytes 99.5 3074
NP_001074771.1 Trio gene product M. musculus 98.6 3102
NP_001097996.1 triple functional domain protein D. rerio 90.4 3034
NP_001121262.1 kalirin, RhoGEF kinase X. laevis 58.4 633
NP_001021499.1 Protein UNC-73, isoform d C. elegans 54.1 270
NP_651960.2 trio, isoform A D. melanogaster 53.0 2174
Other hits (2 of 34) [Show all]SpeciesId(%)Len(aa)
XP_003133886.3 PREDICTED: triple functional domain protein S. scrofa 99.2 661
XP_002714128.1 PREDICTED: triple functional domain (PTPRF interacting)-like O. cuniculus 99.0 3033

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; lung; mixed; liver; trachea; eye; bone marrow; embryonic tissue; amniotic fluid; intestine; mammary gland; nerve; pancreas; lymph node; bone; prostate; mouth; kidney; connective tissue; skin; larynx; muscle; placenta; thyroid; uterus; testis; stomach; ovary; heart; vascular; pituitary gland; blood; parathyroid; lymph; ascites; bladder; ganglia; cervix; adrenal gland; thymus
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 5
Map position: 5p15.2
UniSTS entry: Chr 5 RH45695
UniSTS entry: Chr 5 HSC2LD052 [Map Viewer]
UniSTS entry: Chr 5 A007A12 [Map Viewer]
UniSTS entry: Chr 5 WI-15727 [Map Viewer]
UniSTS entry: Chr 5 STS-H82060 [Map Viewer]
UniSTS entry: Chr 5 SGC35149 [Map Viewer]
UniSTS entry: Chr 1 D11S2921
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (10)

AF091395.1 Homo sapiens Trio isoform mRNA, complete cds PA
AB115332.1 Homo sapiens tgat mRNA for transforming gene product TGAT, complete cds PA
NM_007118.2 Homo sapiens trio Rho guanine nucleotide exchange factor (TRIO), mRNA PA
AL161955.1 Homo sapiens mRNA; cDNA DKFZp434H0229 (from clone DKFZp434H0229) PA
AK131423.1 Homo sapiens cDNA FLJ16543 fis, clone OCBBF3002654, highly similar to Triple functional domain protein P
AB209754.1 Homo sapiens mRNA for triple functional domain (PTPRF interacting) variant protein P
U42390.1 Homo sapiens Trio mRNA, complete cds P
AK304786.1 Homo sapiens cDNA FLJ57816 complete cds, highly similar to Triple functional domain protein PA
BC017268.2 Homo sapiens triple functional domain (PTPRF interacting), mRNA (cDNA clone IMAGE:4586722), partial cds PA
BC035585.1 Homo sapiens, Similar to triple functional domain (PTPRF interacting), clone IMAGE:5497679, mRNA, partial cds P

EST sequences (10 of 565) [Show all sequences]

AA972243.1 Clone IMAGE:1584444 lung 3' read
AA907599.1 Clone IMAGE:1540596 mixed 3' read
AI015354.1 Clone IMAGE:1637340 uncharacterized tissue 3' read P
AI042333.1 Clone IMAGE:1668041 parathyroid 3' read P
R20981.1 Clone IMAGE:31378 brain 5' read P
AI093879.1 Clone IMAGE:1688289 mixed 3' read A
AI096523.1 Clone IMAGE:1704555 brain 3' read A
AI126701.1 Clone IMAGE:1707739 heart 3' read A
AI140163.1 Clone IMAGE:1693783 heart 3' read
AI141472.1 Clone IMAGE:1691852 heart 3' read P

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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