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UGID:132862     UniGene Hs.12253     Homo sapiens (human)   SMAD2
SMAD family member 2 (SMAD2)

Human protein-coding gene SMAD2. Represented by 448 ESTs from 220 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 132862 - Hs.12253]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_034884.2 Smad2 gene product M. musculus 100.0 466
NP_062064.1 Smad2 gene product R. norvegicus 100.0 466
XP_001365064.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 1 M. domestica 100.0 466
XP_001086616.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 3 M. mulatta 100.0 466
XP_003914405.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 1 P. anubis 100.0 466
XP_001149585.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 4 P. troglodytes 100.0 466
NP_001003652.1 SMAD2 gene product H. sapiens 100.0 466
XP_852799.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 2 C. lupus familiaris 100.0 466
XP_001916389.2 PREDICTED: LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2 E. caballus 100.0 466
NP_001039683.1 SMAD2 gene product B. taurus 100.0 466
XP_004020581.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 1 O. aries 100.0 466
XP_002713567.1 PREDICTED: Sma- and Mad-related protein 2-like isoform 2 O. cuniculus 100.0 466
NP_001243077.1 mothers against decapentaplegic homolog 2 S. scrofa 100.0 436
XP_003216221.1 PREDICTED: mothers against decapentaplegic homolog 2-like isoform 2 A. carolinensis 99.8 466
NP_989892.1 SMAD2 gene product G. gallus 99.8 466
NP_001084329.1 Mad2 protein X. laevis 99.6 466
NP_001011168.1 smad2 gene product X. tropicalis 99.6 466
XP_002194017.1 PREDICTED: mothers against decapentaplegic homolog 2 isoform 1 T. guttata 99.6 464
NP_571441.2 smad2 gene product D. rerio 97.4 467
NP_511079.1 smad on X D. melanogaster 77.2 485
NP_498931.2 Protein SMA-2 C. elegans 57.5 401
Other hits (2 of 24) [Show all]SpeciesId(%)Len(aa)
XP_003448638.1 PREDICTED: mothers against decapentaplegic homolog 2 O. niloticus 97.2 466
XP_004072808.1 PREDICTED: mothers against decapentaplegic homolog 2-like O. latipes 97.0 466

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; mixed; uncharacterized tissue; placenta; blood; adipose tissue; thyroid; vascular; muscle; pituitary gland; larynx; kidney; lymph node; cervix; lung; intestine; uterus; stomach; embryonic tissue; liver; spleen; lymph; testis; heart; skin; prostate; pharynx; eye; adrenal gland; mammary gland; bladder; mouth; connective tissue; thymus; ear; ascites; ovary; nerve; bone; pancreas; bone marrow; ganglia; parathyroid
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 18
Map position: 18q21.1
UniSTS entry: Chr 18 RH47015 [Map Viewer]
UniSTS entry: Chr 18 RH17857 [Map Viewer]
UniSTS entry: Chr 18 MARC_10275-10276:998924078:1
UniSTS entry: Smad2
UniSTS entry: Chr 18 RH12141 [Map Viewer]
UniSTS entry: Chr 18 D18S1312 [Map Viewer]
UniSTS entry: Chr 18 WIAF-1471 [Map Viewer]
UniSTS entry: Chr 18 SHGC-64255
UniSTS entry: Chr 18 RH66619 [Map Viewer]
UniSTS entry: Chr 18 MADH2_1658
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

BT007422.1 Homo sapiens MAD, mothers against decapentaplegic homolog 2 (Drosophila) mRNA, complete cds P
AY134745.1 Homo sapiens medulloblastoma antigen MU-MB-50.13 mRNA, complete cds A
AK126373.1 Homo sapiens cDNA FLJ44409 fis, clone TUTER2002356
NM_005901.5 Homo sapiens SMAD family member 2 (SMAD2), transcript variant 1, mRNA P
NM_001003652.3 Homo sapiens SMAD family member 2 (SMAD2), transcript variant 2, mRNA P
BC014840.1 Homo sapiens SMAD family member 2, mRNA (cDNA clone MGC:22139 IMAGE:4449540), complete cds PA
U59911.1 Human chromosome 18 Mad homolog JV18-1 mRNA, complete cds PA
AK312963.1 Homo sapiens cDNA, FLJ93422, Homo sapiens MAD, mothers against decapentaplegic homolog 2(Drosophila) (MADH2), mRNA P
BC025699.1 Homo sapiens SMAD family member 2, mRNA (cDNA clone MGC:34440 IMAGE:5221801), complete cds PA
U68018.1 Human mad protein homolog (hMAD-2) mRNA, complete cds P
U65019.1 Human MAD-related protein 2 (MADR2) mRNA, complete cds P
NM_001135937.2 Homo sapiens SMAD family member 2 (SMAD2), transcript variant 3, mRNA P
AF027964.1 Homo sapiens MAD-related protein Smad2 mRNA, complete cds P

EST sequences (10 of 448) [Show all sequences]

R14120.1 Clone IMAGE:27538 brain 5' read
AI015746.1 Clone IMAGE:1622572 embryonic tissue 3' read
AI073680.1 Clone IMAGE:1664390 skin 3' read A
AI087928.1 Clone IMAGE:1566758 mixed 3' read A
AI091738.1 Clone IMAGE:1651163 mixed 3' read A
AI093802.1 Clone IMAGE:1688457 mixed 3' read PA
AA947466.1 Clone IMAGE:1508406 mixed 3' read
CB045729.1 Clone IMAGE:3218305 intestine 3' read A
CB045730.1 Clone IMAGE:3218305 intestine 5' read
BX104905.1 Clone IMAGp998D01194_;_IMAGE:135888 placenta


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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