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UGID:144805     UniGene Hs.116237     Homo sapiens (human)   VAV1
Vav 1 guanine nucleotide exchange factor (VAV1)

Human protein-coding gene VAV1. Represented by 106 ESTs from 51 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 144805 - Hs.116237]

Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_005419.2 VAV1 gene product H. sapiens 100.0 844
XP_512321.3 PREDICTED: proto-oncogene vav isoform 2 P. troglodytes 100.0 788
XP_003914821.1 PREDICTED: proto-oncogene vav-like, partial P. anubis 99.5 659
NP_035821.3 Vav1 gene product M. musculus 95.5 844
NP_001086991.1 vav 1 oncogene X. laevis 75.7 844
NP_001119865.1 guanine nucleotide exchange factor VAV3 D. rerio 62.9 821
Other hits (2 of 20) [Show all]SpeciesId(%)Len(aa)
XP_542134.2 PREDICTED: proto-oncogene vav C. lupus familiaris 97.3 844
NP_001254762.1 vav 1 guanine nucleotide exchange factor S. scrofa 96.8 844

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: thymus; embryonic tissue; bone marrow; uterus; uncharacterized tissue; brain; mixed; blood; pancreas; prostate; eye; lymph; ascites; testis; spleen; pharynx; lung; lymph node; trachea; ovary; placenta; connective tissue; mouth; bone
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 19
Map position: 19p13.2
UniSTS entry: Chr 19 RH80857
UniSTS entry: Chr 19 MARC_12285-12286:1008002533:1
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (9)

NM_005428.3 Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 1, mRNA PA
AK225710.1 Homo sapiens mRNA for vav 1 oncogene variant, clone: TMS02340 PA
BC013361.2 Homo sapiens vav 1 guanine nucleotide exchange factor, mRNA (cDNA clone MGC:15356 IMAGE:3842829), complete cds PA
AK313307.1 Homo sapiens cDNA, FLJ93820, highly similar to Homo sapiens vav 1 oncogene (VAV1), mRNA P
AK301128.1 Homo sapiens cDNA FLJ53479 complete cds, highly similar to Proto-oncogene vav PA
X83931.1 H.sapiens mRNA for VAV oncogene P
X16316.1 Human mRNA for vav oncogene P
NM_001258207.1 Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 3, mRNA PA
NM_001258206.1 Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 2, mRNA PA

EST sequences (10 of 106) [Show all sequences]

CB529026.1 Clone UI-H-FT2-bje-j-16-0-UI lung 3' read PA
AI886722.1 Clone IMAGE:2412774 lymph node 3' read A
AI886795.1 Clone IMAGE:2412851 lymph node 3' read A
AI586976.1 Clone IMAGE:2259802 brain 3' read A
BX362424.2 Clone CS0DJ015YC13 blood 5' read P
BX374047.2 Clone CS0DJ015YC13 blood 3' read P
BX369494.1 Clone CS0DJ015YC13 blood 5' read P
CD742670.1 Clone UI-H-FT2-bjo-k-12-0-UI lung 3' read PA
AW105491.1 Clone IMAGE:2597516 ovary 3' read A
AW316763.1 Clone IMAGE:2836686 pancreas 3' read

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

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