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UGID:132683     UniGene Hs.10734     Homo sapiens (human)   CHRNA4
Cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4)

Human protein-coding gene CHRNA4. Represented by 46 ESTs from 31 cDNA libraries. Corresponds to 3 reference sequences (different isoforms). [UniGene 132683 - Hs.10734]

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with RefSeq proteins. The alignments can suggest function of the cluster.
Best Hits and Hits from model organismsSpeciesId(%)Len(aa)
NP_000735.1 CHRNA4 gene product H. sapiens 100.0 626
NP_056545.3 Chrna4 gene product M. musculus 90.9 628
NP_001041528.1 chrna4 gene product D. rerio 72.3 617
NP_001086549.1 cholinergic receptor, nicotinic, alpha 5 (neuronal) precursor X. laevis 62.6 337
NP_001097669.2 nicotinic acetylcholine receptor alpha 80B, isoform C D. melanogaster 56.6 348
NP_491533.2 Protein UNC-63 C. elegans 54.4 362
Other hits (2 of 38) [Show all]SpeciesId(%)Len(aa)
NP_001029286.1 CHRNA4 gene product P. troglodytes 99.2 626
XP_003904551.1 PREDICTED: neuronal acetylcholine receptor subunit alpha-4 P. anubis 98.1 625

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO Profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; testis; uncharacterized tissue; eye; liver; kidney; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 20
Map position: 20q13.2-q13.3
UniSTS entry: Chr 20 RH12050
UniSTS entry: Chr 20 RH75305
UniSTS entry: Chr 20 RH78607
UniSTS entry: Chr 20 RH64135
UniSTS entry: Chr 20 RH70691
UniSTS entry: Chr 20 D20S127E
UniSTS entry: Chr 20 CHRNA4_1625
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

NM_000744.6 Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), transcript variant 1, mRNA P
BC096290.1 Homo sapiens cholinergic receptor, nicotinic, alpha 4, mRNA (cDNA clone MGC:116962 IMAGE:40007296), complete cds P
BC096292.1 Homo sapiens cholinergic receptor, nicotinic, alpha 4, mRNA (cDNA clone MGC:116964 IMAGE:40007298), complete cds P
BC096293.3 Homo sapiens cholinergic receptor, nicotinic, alpha 4, mRNA (cDNA clone MGC:116965 IMAGE:40007299), complete cds P
BC096291.1 Homo sapiens cholinergic receptor, nicotinic, alpha 4, mRNA (cDNA clone MGC:116963 IMAGE:40007297), complete cds P
L35901.1 Human nicotinic acetylcholine receptor alpha 4 subunit (nAChR) mRNA, complete cds P
AK314907.1 Homo sapiens cDNA, FLJ95812 P
AK296430.1 Homo sapiens cDNA FLJ56655 complete cds P
X87629.1 H.sapiens mRNA for nicotinic acetylcholine receptor alpha4 subunit P
NM_001256573.1 Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), transcript variant 2, mRNA P
NR_046317.1 Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), transcript variant 3, non-coding RNA P
Y08421.1 H.sapiens mRNA for nicotinic acetylcholine receptor alpha4 subunit precursor P

EST sequences (10 of 46) [Show all sequences]

AA985359.1 Clone IMAGE:1629469 brain 3' read
R19915.1 Clone IMAGE:34821 brain 5' read
BX097221.1 Clone IMAGp998B093634_;_IMAGE:1437608 liver A
CB156220.1 Clone B2N807043-9-A07 brain 5' read
R56603.1 Clone IMAGE:41074 brain 5' read
R56604.1 Clone IMAGE:41074 brain 3' read A
AI937242.1 Clone IMAGE:2467554 brain 3' read
Z44054.1 Clone c-1rd09 brain
Z40094.1 Clone c-1rd09 brain 3' read A
CR743277.1 Clone IMAGp998G10342_;_IMAGE:183969 brain 5' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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