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1BI7: 
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
Biological unit 1: tetrameric
Source organism: Homo sapiens
Number of proteins:
4 (CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPR... ▼)
Protein molecule
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AA -Click to explore this molecule neighborsA_1A_1 -Click to explore this molecule neighbors
 CYCLIN-DEPENDENT KINASE 6
BB -Click to explore this molecule neighborsB_1B_1 -Click to explore this molecule neighbors
 MULTIPLE TUMOR SUPPRESSOR
Similar Structures (5718)help
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Showing 1 to 10 out of 5718 selected structures help
      PDB ID Description Taxonomy▲▼ Aligned Protein▲▼ RMSD▲▼ Aligned Residues▲▼ Sequence Identity▲▼
1
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Partial
 4UY9
Structure of MLK1 kinase domain with leucine zipper 1
Homo sapiens
 2 5.20Å 421 26%
2
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Partial
 1G3N
STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX
Others
 2 2.02Å 389 80%
3
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Partial
 1BI8
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX
Homo sapiens
 2 1.37Å 387 81%
4
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Partial
 1BLX
P19INK4D/CDK6 COMPLEX
Homo sapiens/Mus musculus
 2 1.45Å 374 83%
5
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Partial
 2O5K
Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor
Homo sapiens
 1 3.62Å 252 26%
6
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Partial
 2W99
Crystal Structure of CDK4 in complex with a D-type cyclin
Homo sapiens
 1 2.51Å 250 70%
7
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Partial
 6HK7
Crystal structure of GSK-3B in complex with pyrazine inhibitor C50
Homo sapiens
 1 3.21Å 250 28%
8
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Partial
 6HK3
Crystal structure of GSK-3B in complex with pyrazine inhibitor C44
Homo sapiens
 1 3.25Å 250 28%
9
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Partial
 1J1B
Binary complex structure of human tau protein kinase I with AMPPNP
Homo sapiens
 1 3.32Å 250 27%
10
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Partial
 3G33
Crystal structure of CDK4/cyclin D3
Homo sapiens
 1 2.24Å 249 68%
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{"1":"CYCLIN-DEPENDENT KINASE 6","2":"MULTIPLE TUMOR SUPPRESSOR","3":"CYCLIN-DEPENDENT KINASE 6","4":"MULTIPLE TUMOR SUPPRESSOR"}
Citing VAST
Gibrat JF, Madej T, Bryant SH. "Surprising similarities in structure comparison.", Curr Opin Struct Biol.1996 Jun;6(3):377-85
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. "MMDB and VAST+: tracking structural similarities between macromolecular complexes." Nucl. Acids Res. 2014 Jan;42(Database issue):D297-303
Thomas Madej, Aron Marchler-Bauer, Christopher Lanczycki, Dachuan Zhang, Stephen H Bryant "Biological Assembly Comparison With VAST" Methods Mol. Biol. 2020(2112):175-186
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?Original VAST
Original VAST finds structures that are similar to individual protein molecules, or individual 3D domains, in your query structure. Select a protein molecule ("chain") or 3D domain of interest from the table below to view a list of other proteins or domains that have a similar 3D shape. In contrast to VAST+, which focuses on the default biological unit, Original VAST lists all protein molecules in the asymmetric unit of the query structure.