2V0M: VAST+ Similar Structure Assemblies and Proteins

National Center for
Biotechnology Information

Crystal structure of human P450 3A4 in complex with ketoconazole

Biological unit 1: monomeric

Source organism: Homo sapiens

Number of proteins:

1 (CYTOCHROME P450 3A4)

Number of chemicals:

3 (PROTOPORPHYRIN IX CONTAINING FE,1-ACETYL-4-(4-{... ▼)

Chemical

	PROTOPORPHYRIN IX CONTAINING FE
	1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE (2)

Similar Structures (952)

			PDB ID	Description	Taxonomy▲▼	Aligned Protein▲▼	RMSD▲▼	Aligned Residues▲▼	Sequence Identity▲▼
1	Expand row	Full	5VCG	Crystal structure of the cysteine depleted CYP3A4 bound to bromoergocryptine	Homo sapiens	1	1.52Å	454	98%
2	Expand row	Full	6BD7	Crystal structure of human CYP3A4 bound to an inhibitor	Homo sapiens	1	1.55Å	454	100%
3	Expand row	Full	6BDI	Crystal structure of human CYP3A4 bound to an inhibitor	Homo sapiens	1	1.56Å	454	100%
4	Expand row	Full	6BDK	Crystal structure of human CYP3A4 bound to an inhibitor	Homo sapiens	1	1.56Å	454	100%
5	Expand row	Full	6MA8	Human CYP3A4 bound to PMSF	Homo sapiens	1	1.58Å	454	100%
6	Expand row	Full	4D6Z	Cytochrome P450 3A4 bound to imidazole and an inhibitor	Homo sapiens	1	1.61Å	454	100%
7	Expand row	Full	6MA7	Human CYP3A4 bound to an inhibitor fluconazole	Homo sapiens	1	1.62Å	454	99%
8	Expand row	Full	3NXU	Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir	Homo sapiens	1	0.63Å	453	100%
9	Expand row	Full	4I4H	Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir	Homo sapiens	1	0.65Å	453	100%
10	Expand row	Full	4K9W	Complex of human CYP3A4 with a desoxyritonavir analog	Homo sapiens	1	0.68Å	453	100%

{"1":"CYTOCHROME P450 3A4"}