5J80: VAST+ Similar Structure Assemblies and Proteins

National Center for
Biotechnology Information

Crystal Structure of Apo Hsp90-alpha N-domain L107A mutant

Biological unit 1: dimeric

Source organism: Homo sapiens

Number of proteins:

2 (Heat shock protein HSP 90-alpha ▼)

Protein molecule

Heat shock protein HSP 90-alpha

Similar Structures (567)

			PDB ID	Description	Taxonomy▲▼	Aligned Protein▲▼	RMSD▲▼	Aligned Residues▲▼	Sequence Identity▲▼
1	Expand row	Full	2BT0	Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design	Homo sapiens	2	0.54Å	414	99%
2	Expand row	Full	5FND	Dynamic Undocking and the Quasi-Bound State as tools for Drug Design	Homo sapiens	2	0.65Å	414	99%
3	Expand row	Full	2VCI	4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer	Homo sapiens	2	0.66Å	414	99%
4	Expand row	Full	2YE6	HSP90 inhibitors and drugs from fragment and virtual screening	Homo sapiens	2	0.68Å	414	99%
5	Expand row	Full	2YE4	HSP90 inhibitors and drugs from fragment and virtual screening	Homo sapiens	2	0.71Å	414	99%
6	Expand row	Full	2YI6	Structural Characterization Of 5-Aryl-4-(5-Substituted-2- 4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors	Homo sapiens	2	0.77Å	414	99%
7	Expand row	Full	2YI7	Structural Characterization Of 5-Aryl-4-(5-Substituted-2-4- Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors	Homo sapiens	2	0.86Å	414	99%
8	Expand row	Full	2BSM	Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design	Homo sapiens	2	0.86Å	414	99%
9	Expand row	Full	2YE5	HSP90 inhibitors and drugs from fragment and virtual screening	Homo sapiens	2	0.87Å	414	99%
10	Expand row	Full	2YEB	HSP90 inhibitors and drugs from fragment and virtual screening	Homo sapiens	2	0.87Å	414	99%

{"1":"Heat shock protein HSP 90-alpha","379":"Heat shock protein HSP 90-alpha"}

	Full	Complete match, 2 proteins (45)	–
	Partial	Partial match, 1 protein (522)	–