Skip to main page content

basic helix-loop-helix domain-containing protein

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Saccharomyces cerevisiae protein INO2 that acts as positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes

Arch. IDVersionDate PublishedReview Level
1441298912022-03-14
curated
Arch. ID14412989
Version1
Date Published2022-03-14
Review Level
curated
bHLH_ScINO2_like: basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteinsbHLH_ScINO2_like
Gene Ontology:  GO:0003677
PubMed:  20219281
Thank you for your feedback!
Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsbasic helix-loop-helix domain-containing proteinbasic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Saccharomyces cerevisiae protein INO2 that acts as positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes
Name, label and taxonomic scope
Tax. ExpAll organisms
Namebasic helix-loop-helix domain-containing protein
Labelbasic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Saccharomyces cerevisiae protein INO2 that acts as positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes
Supporting evidence
CDD
  • cd11388: bHLH_ScINO2_like : basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins
Protein Accession
  • P26798: RecName: Full=Protein INO2
  • A0A0U2WFX7: RecName: Full=Regulator of itaconic acid biosynthesis; AltName: Full=Itaconic acid/2-hydroxyparaconate biosynthesis cluster protein RIA1
  • BAA14424: SCSI [Saccharomyces cerevisiae]
Gene IDs
Publications
  • PMID 1620625: The INO2 gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid synthesis.
  • PMID 8188619: Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis.
  • PMID 8012448: INO2, a regulatory gene in yeast phospholipid biosynthesis, affects nuclear segregation and bud pattern formation.
  • PMID 20219281: Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
Conserved domains in this architecture
AccessionShort nameTitle
cd11388bHLH_ScINO2_likebasic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins
Functional sites in this architecture
TitleTypeSource domain
putative DNA binding sitenucleotide bindingcd11388
putative dimer interfacepolypeptide bindingcd11388

    HHS Vulnerability Disclosure