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non-ribosomal peptide synthetase

non-ribosomal peptide synthetase is a modular multidomain enzyme that acts as an assembly line to catalyze the biosynthesis of complex natural products

Arch. IDVersionDate PublishedReview Level
1346271622019-05-24
curated
Arch. ID13462716
Version2
Date Published2019-05-24
Review Level
curated
entF: enterobactin non-ribosomal peptide synthetase EntFentFA_NRPS_TlmIV_like: The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genesA_NRPS_TlmIV_likeMethyltransf_12: Methyltransferase domainMethyltransf_12PRK12467: peptide synthasePRK12467
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsnon-ribosomal peptide synthetasenon-ribosomal peptide synthetase is a modular multidomain enzyme that acts as an assembly line to catalyze the biosynthesis of complex natural products
Name, label and taxonomic scope
Tax. ExpAll organisms
Namenon-ribosomal peptide synthetase
Labelnon-ribosomal peptide synthetase is a modular multidomain enzyme that acts as an assembly line to catalyze the biosynthesis of complex natural products
Supporting evidence
Comments
  • also contains a methytransferase domain
CDD
  • cd12114: A_NRPS_TlmIV_like
  • cd17646: A_NRPS_AB3403-like
  • pfam00975: Thioesterase
  • cd05930: A_NRPS : The adenylation domain of nonribosomal peptide synthetases (NRPS)
  • PRK12467: peptide synthase; Provisional
  • COG1020: EntF : Non-ribosomal peptide synthetase component F [Secondary metabolites biosynthesis, transport and catabolism]
  • pfam00668: Condensation : Condensation domain
Publications
  • PMID 29444491: Piecing together nonribosomal peptide synthesis.
  • PMID 26429504: A structural model for multimodular NRPS assembly lines.
  • PMID 20153164: Nonribosomal peptide synthetases: structures and dynamics.
Protein Accession
  • RQC15975: non-ribosomal peptide synthetase [Pseudomonas aeruginosa]
Conserved domains in this architecture
AccessionShort nameTitle
cd12114A_NRPS_TlmIV_likeThe adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes
cl35902entFenterobactin non-ribosomal peptide synthetase EntF
cl36129PRK12467peptide synthase
pfam08242Methyltransf_12Methyltransferase domain
Functional sites in this architecture
TitleTypeSource domain
AMP binding sitechemical bindingcd12114
acyl-activating enzyme (AAE) consensus motifothercd12114

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