M14 family zinc carboxypeptidase N/E relies on its substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell; it contains an extra C-terminal domain which may assist in folding of the carboxypeptidase domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes
Arch. ID
Version
Date Published
Review Level
13339157
2
2021-08-26
curated
Arch. ID
13339157
Version
2
Date Published
2021-08-26
Review Level
curated
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
M14 family zinc carboxypeptidase N/E relies on its substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell; it contains an extra C-terminal domain which may assist in folding of the carboxypeptidase domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes
Name, label and taxonomic scope
Tax. Exp
All organisms
Name
M14 family carboxypeptidase N/E
Label
M14 family zinc carboxypeptidase N/E relies on its substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell; it contains an extra C-terminal domain which may assist in folding of the carboxypeptidase domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes
Supporting evidence
Comments
also contains N-terminal TonB domain, and coagulation factor 5/8 C-terminal domain (discoidin domain) assumed to have horizontally transferred to eubacterial genomes
such as carboxypeptidase (CP)-like protein X (CPX) or adipocyte enhancer binding protein-1 (AEBP1) which are enzymatically non-active towards standard CP substrates because they lack one or more critical active site and substrate-binding residues needed for activity; they may function as binding proteins or display catalytic activity toward other substrates
Q8N436: RecName: Full=Inactive carboxypeptidase-like protein X2; Flags: Precursor
AAI37493: Carboxypeptidase X (M14 family), member 2 [Homo sapiens]
Publications
PMID 31651348: Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma.
PMID 9809751: Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization.