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CUGBP Elav-like family protein

CUGBP Elav-like family protein belongs to the CUGBP1 and ETR-3-like factors (CELF) or BRUNOL (Bruno-like) family of RNA-binding proteins that display dual nuclear and cytoplasmic localizations and have been implicated in the regulation of pre-mRNA splicing and in the control of mRNA translation and deadenylation

Arch. IDVersionDate PublishedReview Level
1298124012018-12-13
curated
Arch. ID12981240
Version1
Date Published2018-12-13
Review Level
curated
RRM2_CELF3_4_5_6: RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteinsRRM2_CELF3_4_5_6U2AF_lg: U2 snRNP auxilliary factor, large subunit, splicing factorU2AF_lgRRM3_CELF3_4_5_6: RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteinsRRM3_CELF3_4_5_6
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsCUGBP Elav-like family proteinCUGBP Elav-like family protein belongs to the CUGBP1 and ETR-3-like factors (CELF) or BRUNOL (Bruno-like) family of RNA-binding proteins that display dual nuclear and cytoplasmic localizations and have been implicated in the regulation of pre-mRNA splicing and in the control of mRNA translation and deadenylation
Name, label and taxonomic scope
Tax. ExpAll organisms
NameCUGBP Elav-like family protein
LabelCUGBP Elav-like family protein belongs to the CUGBP1 and ETR-3-like factors (CELF) or BRUNOL (Bruno-like) family of RNA-binding proteins that display dual nuclear and cytoplasmic localizations and have been implicated in the regulation of pre-mRNA splicing and in the control of mRNA translation and deadenylation
Supporting evidence
Gene IDs
CDD
  • TIGR01628: PABP-1234 : polyadenylate binding protein, human types 1, 2, 3, 4 family
  • cd12639: RRM3_CELF3_4_5_6 : RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  • cd12632: RRM1_CELF3_4_5_6 : RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  • cd12635: RRM2_CELF3_4_5_6 : RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  • cd12638: RRM3_CELF1_2 : RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
Publications
  • PMID 17393433: Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile.
  • PMID 11158314: The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.
  • PMID 10893231: A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.
  • PMID 17584860: Cloning and embryonic expression patterns of the chicken CELF family.
Protein Accession
  • NP_001344715: CUGBP Elav-like family member 3 isoform 7 [Mus musculus]
  • NP_001298021: CUGBP Elav-like family member 6 isoform 2 [Mus musculus]
Conserved domains in this architecture
AccessionShort nameTitle
cd12635RRM2_CELF3_4_5_6RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
cd12639RRM3_CELF3_4_5_6RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
cl36941U2AF_lgU2 snRNP auxilliary factor, large subunit, splicing factor
Functional sites in this architecture
TitleTypeSource domain
putative RNA binding sitenucleotide bindingcd12635

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