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type I polyketide synthase

type I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks

Arch. IDVersionDate PublishedReview Level
1222052922022-03-11
curated
Arch. ID12220529
Version2
Date Published2022-03-11
Review Level
curated
PKS_AT: Acyl transferase domain in polyketide synthase (PKS) enzymesPKS_ATKR_1_SDR_x: ketoreductase (KR), subgroup 1, complex (x) SDRsKR_1_SDR_xPKS_PP: Phosphopantetheine attachment sitePKS_PPPksD: Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]PksDKR_3_FAS_SDR_x: beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x)KR_3_FAS_SDR_xPKS_PP: Phosphopantetheine attachment sitePKS_PP
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismstype I polyketide synthasetype I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks
Name, label and taxonomic scope
Tax. ExpAll organisms
Nametype I polyketide synthase
Labeltype I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks
Supporting evidence
CDD
  • smart00823: PKS_PP : Phosphopantetheine attachment site
  • cd08952: KR_1_SDR_x
  • COG3321: PksD : Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
  • smart00827: PKS_AT
  • cd08956: KR_3_FAS_SDR_x
Protein Accession
  • CDR03855: modular polyketide synthase [Streptomyces iranensis]
Conserved domains in this architecture
AccessionShort nameTitle
COG3321PksDAcyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
cd08952KR_1_SDR_xketoreductase (KR), subgroup 1, complex (x) SDRs
cd08956KR_3_FAS_SDR_xbeta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x)
smart00823PKS_PPPhosphopantetheine attachment site
smart00827PKS_ATAcyl transferase domain in polyketide synthase (PKS) enzymes
Functional sites in this architecture
TitleTypeSource domain
active siteactivecd08952
NADP binding sitechemical bindingcd08952
active siteactivecd08956
putative NADP binding sitechemical bindingcd08956

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