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type I polyketide synthase

type I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks

Arch. IDVersionDate PublishedReview Level
1222010322021-10-18
curated
Arch. ID12220103
Version2
Date Published2021-10-18
Review Level
curated
PKS_PP: Phosphopantetheine attachment sitePKS_PPPksD: Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]PksDKR_2_SDR_x: ketoreductase (KR), subgroup 2, complex (x) SDRsKR_2_SDR_x
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismstype I polyketide synthasetype I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks
Name, label and taxonomic scope
Tax. ExpAll organisms
Nametype I polyketide synthase
Labeltype I polyketide synthase assembles complex polyketides via the head-to-tail fusion of acyl and malonyl building blocks
Supporting evidence
Protein Accession
  • AUM64932: polyketide synthase [Brevibacillus laterosporus]
CDD
  • smart00823: PKS_PP : Phosphopantetheine attachment site
  • COG3321: PksD : Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
  • cd08953: KR_2_SDR_x
Conserved domains in this architecture
AccessionShort nameTitle
COG3321PksDAcyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
cd08953KR_2_SDR_xketoreductase (KR), subgroup 2, complex (x) SDRs
smart00823PKS_PPPhosphopantetheine attachment site
Functional sites in this architecture
TitleTypeSource domain
active siteactivecd08953
putative NADP binding sitechemical bindingcd08953

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