AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence
Arch. ID
Version
Date Published
Review Level
11825659
1
2017-02-03
curated
Arch. ID
11825659
Version
1
Date Published
2017-02-03
Review Level
curated
Thank you for your feedback!
Sequences with this architecture
This architecture currently does not link to any protein sequence records.
AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence
Name, label and taxonomic scope
Tax. Exp
All organisms
Name
AraC family transcriptional regulator
Label
AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence
Supporting evidence
Comments
from 10582496: AraC family transcriptional regulators have a conserved stretch of amino acids located at the C-terminal or N-terminal region of the regulator that contains alpha-helix-turn--helix DNA binding motif(s) connected to the non-conserved effector region via a linker
from 10582496: cupin (from the Latin term ?cupa,? for a small barrel or cask) is a beta-barrel structural domain identified in a superfamily of prokaryotic and eukaryotic proteins that are extremely diverse and includes catalytically inactive seed storage proteins, sugar-binding metal-independent epimerases, and metal-dependent enzymes possessing dioxygenase, decarboxylase, and other activities
from 10582496: AraC (a regulator of the arabinose pathway in E. coli) family transcription regulator, contains more than 100 members, involved in carbon metabolism, stress responses, and pathogenesis, with the former category including factors that control the degradation of arabinose (AraC), cellobiose (CelD/ChbR), melibiose (MelR), raffinose (RafR), rhamnose (RhaR), and xylose (XylR)
Publications
PMID 22505803: Computer-based annotation of putative AraC/XylS-family transcription factors of known structure but unknown function.
PMID 17712603: The DNA-binding domain as a functional indicator: the case of the AraC/XylS family of transcription factors.
PMID 10704478: Microbial relatives of the seed storage proteins of higher plants: conservation of structure and diversification of function during evolution of the cupin superfamily.
CDD
pfam00165: HTH_AraC : Bacterial regulatory helix-turn-helix proteins, AraC family