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AraC family transcriptional regulator

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Arch. IDVersionDate PublishedReview Level
1182565912017-02-03
curated
Arch. ID11825659
Version1
Date Published2017-02-03
Review Level
curated
Obsolete: This domain/cluster is obsoleteObsoleteHTH_18: Helix-turn-helix domainHTH_18AraC: AraC-type DNA-binding domain and AraC-containing proteins [Transcription]AraC
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsAraC family transcriptional regulatorAraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence
Name, label and taxonomic scope
Tax. ExpAll organisms
NameAraC family transcriptional regulator
LabelAraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence
Supporting evidence
Comments
  • from 10582496: AraC family transcriptional regulators have a conserved stretch of amino acids located at the C-terminal or N-terminal region of the regulator that contains alpha-helix-turn--helix DNA binding motif(s) connected to the non-conserved effector region via a linker
  • from 10582496: cupin (from the Latin term ?cupa,? for a small barrel or cask) is a beta-barrel structural domain identified in a superfamily of prokaryotic and eukaryotic proteins that are extremely diverse and includes catalytically inactive seed storage proteins, sugar-binding metal-independent epimerases, and metal-dependent enzymes possessing dioxygenase, decarboxylase, and other activities
  • from 10582496: AraC (a regulator of the arabinose pathway in E. coli) family transcription regulator, contains more than 100 members, involved in carbon metabolism, stress responses, and pathogenesis, with the former category including factors that control the degradation of arabinose (AraC), cellobiose (CelD/ChbR), melibiose (MelR), raffinose (RafR), rhamnose (RhaR), and xylose (XylR)
Publications
  • PMID 22505803: Computer-based annotation of putative AraC/XylS-family transcription factors of known structure but unknown function.
  • PMID 17712603: The DNA-binding domain as a functional indicator: the case of the AraC/XylS family of transcription factors.
  • PMID 10704478: Microbial relatives of the seed storage proteins of higher plants: conservation of structure and diversification of function during evolution of the cupin superfamily.
CDD
  • pfam00165: HTH_AraC : Bacterial regulatory helix-turn-helix proteins, AraC family
Protein Accession
  • CBG91552: AraC-family transcriptional regulator [Citrobacter rodentium ICC168]
Conserved domains in this architecture
AccessionShort nameTitle
COG2207AraCAraC-type DNA-binding domain and AraC-containing proteins [Transcription]
cl26290ObsoleteThis domain/cluster is obsolete
pfam12833HTH_18Helix-turn-helix domain

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