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2-oxoglutarate dehydrogenase subunit E1

2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate

Arch. IDVersionDate PublishedReview Level
1106870012017-12-28
curated
Arch. ID11068700
Version1
Date Published2017-12-28
Review Level
curated
2-oxogl_dehyd_N: 2-oxoglutarate dehydrogenase N-terminus2-oxogl_dehyd_NTPP_E1_OGDC_like: Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding moduleTPP_E1_OGDC_likeRRF: Ribosome recycling factor (RRF)RRFTransket_pyr: Transketolase, pyrimidine binding domainTransket_pyrObsolete: This domain/cluster is obsoleteObsolete
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organisms2-oxoglutarate dehydrogenase subunit E12-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
Name, label and taxonomic scope
Tax. ExpAll organisms
Name2-oxoglutarate dehydrogenase subunit E1
Label2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
Supporting evidence
Comments
  • OGDC-E1, also known as alpha-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex component E1. Re-review[mg] note from Arch 12176651: "name changed in re-curation to 2-oxoglutarate dehydrogenase subunit E1 as suggested by RefSeq staff [AMB]"
E.C. Number
Protein Accession
  • Q8NWR6: RecName: Full=2-oxoglutarate dehydrogenase E1 component; AltName: Full=Alpha-ketoglutarate dehydrogenase
CDD
  • pfam02779: Transket_pyr : Transketolase, pyrimidine binding domain
  • cd02016: TPP_E1_OGDC_like : Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module;...
  • pfam16870: OxoGdeHyase_C : 2-oxoglutarate dehydrogenase C-terminal
Publications
  • PMID 24495017: Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.
Conserved domains in this architecture
AccessionShort nameTitle
cd02016TPP_E1_OGDC_likeThiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module
cl00240RRFRibosome recycling factor (RRF)
cl245972-oxogl_dehyd_N2-oxoglutarate dehydrogenase N-terminus
cl25167ObsoleteThis domain/cluster is obsolete
pfam02779Transket_pyrTransketolase, pyrimidine binding domain
Functional sites in this architecture
TitleTypeSource domain
TPP-binding sitechemical bindingcd02016

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