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sensor histidine kinase

two-component sensor histidine kinase with HAMP signaling domain, similar to the Escherichia coli histidine kinases EnvZ, CpxA, CusS, PcoS, and BaeS, having a variety of functions

Arch. IDVersionDate PublishedReview Level
1086568712016-05-13
curated
Arch. ID10865687
Version1
Date Published2016-05-13
Review Level
curated
HAMP: Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domainHAMPHisKA: His Kinase A (phosphoacceptor) domainHisKAHATPase_c: Histidine kinase-like ATPasesHATPase_c
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismssensor histidine kinasetwo-component sensor histidine kinase with HAMP signaling domain, similar to the Escherichia coli histidine kinases EnvZ, CpxA, CusS, PcoS, and BaeS, having a variety of functions
Name, label and taxonomic scope
Tax. ExpAll organisms
Namesensor histidine kinase
Labeltwo-component sensor histidine kinase with HAMP signaling domain, similar to the Escherichia coli histidine kinases EnvZ, CpxA, CusS, PcoS, and BaeS, having a variety of functions
Supporting evidence
Comments
  • HAMP (as found in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins, and some phosphatases) domains mediate input-output signaling; includes various Escherichia coli two-component sensor histidine kinases such as the osmolarity-sensing EnvZ, the envelope stress sensor CpxA, CusS which functions in Cu(I) and Ag(I) resistance, PcoS in copper resistance, and BaeS in metal homeostasis
Protein Accession
  • CAA58530: pcoS [Escherichia coli]
  • P0AE82: Sensor protein CpxA
  • P18392: Sensor protein RstB
  • Q9L523: Sensor protein SrrB; AltName: Full=Staphylococcal respiratory response protein B
  • AAC64936: CsrS [Streptococcus pyogenes]
Publications
  • PMID 8594334: Molecular genetics and transport analysis of the copper-resistance determinant (pco) from Escherichia coli plasmid pRJ1004.
  • PMID 25993101: 25993101
  • PMID 15522865: Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  • PMID 15060046: Characterization of virulence factor regulation by SrrAB, a two-component system in Staphylococcus aureus.
  • PMID 20690824: Signaling mechanisms of HAMP domains in chemoreceptors and sensor kinases.
  • PMID 22046138: Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.
Conserved domains in this architecture
AccessionShort nameTitle
cd06225HAMPHistidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain
smart00387HATPase_cHistidine kinase-like ATPases
smart00388HisKAHis Kinase A (phosphoacceptor) domain

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