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DENN domain-containing protein

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

Arch. IDVersionDate PublishedReview Level
1065529442023-05-16
curated
Arch. ID10655294
Version4
Date Published2023-05-16
Review Level
curated
uDENN: Domain always found upstream of DENN domain, found in a variety of signalling proteinsuDENNDENN: DENN (AEX-3) domainDENNdDENN: Domain always found downstream of DENN domain, found in a variety of signalling proteinsdDENN
Gene Ontology:  GO:0005085 | GO:0032483
PubMed:  21330364 | 11563850
SCOP:  4007417 | 4006687
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsDENN domain-containing proteinDENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways
Name, label and taxonomic scope
Tax. ExpAll organisms
NameDENN domain-containing protein
LabelDENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways
Supporting evidence
Comments
  • DENN found in a variety of signaling proteins, always encircled by uDENN and dDENN
Publications
  • PMID 21330364: DENN domain proteins: regulators of Rab GTPases.
  • PMID 11563850: uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.
  • PMID 36896567: circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
  • PMID 20937701: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
CDD
  • pfam02141: DENN : DENN (AEX-3) domain
  • smart00800: uDENN : Domain always found upstream of DENN domain, found in a variety of signalling proteins
  • smart00801: dDENN : Domain always found downstream of DENN domain, found in a variety of signalling proteins
Protein Accession
  • Q68D51: RecName: Full=DENN domain-containing protein 2C
  • Q9W3D3: RecName: Full=DENN domain-containing protein Crag; AltName: Full=Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein
Gene IDs
Conserved domains in this architecture
AccessionShort nameTitle
pfam02141DENNDENN (AEX-3) domain
smart00800uDENNDomain always found upstream of DENN domain, found in a variety of signalling proteins
smart00801dDENNDomain always found downstream of DENN domain, found in a variety of signalling proteins

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