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Eisosome component PIL1/LSP1 family protein

Eisosome component PIL1/LSP1 family protein similar to Saccharomyces cerevisiae proteins Pil1 and Lsp1, which together form punctuate clusters (eisosomes) on the cytoplasmic surface of the plasma membrane that mark sites for endocytosis

Arch. IDVersionDate PublishedReview Level
1061915822021-10-15
curated
Arch. ID10619158
Version2
Date Published2021-10-15
Review Level
curated
Pil1: Eisosome component PIL1Pil1
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsEisosome component PIL1/LSP1 family proteinEisosome component PIL1/LSP1 family protein similar to Saccharomyces cerevisiae proteins Pil1 and Lsp1, which together form punctuate clusters (eisosomes) on the cytoplasmic surface of the plasma membrane that mark sites for endocytosis
Name, label and taxonomic scope
Tax. ExpAll organisms
NameEisosome component PIL1/LSP1 family protein
LabelEisosome component PIL1/LSP1 family protein similar to Saccharomyces cerevisiae proteins Pil1 and Lsp1, which together form punctuate clusters (eisosomes) on the cytoplasmic surface of the plasma membrane that mark sites for endocytosis
Supporting evidence
Comments
  • endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalize nutrients in all eukaryotic cells
CDD
Protein Accession
  • P53252: RecName: Full=Sphingolipid long chain base-responsive protein PIL1
  • Q12230: RecName: Full=Sphingolipid long chain base-responsive protein LSP1
  • RDW22982: Eisosome component PIL1/LSP1 [Yarrowia lipolytica]
Gene IDs
Publications
  • PMID 16496001: Eisosomes mark static sites of endocytosis.
  • PMID 15016821: Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p.
Conserved domains in this architecture
AccessionShort nameTitle
pfam13805Pil1Eisosome component PIL1

    HHS Vulnerability Disclosure