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ferritin-like domain-containing protein

ferritin-like domain-containing protein belongs to a broad superfamily of ferritin-like diiron-carboxylate proteins that catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; similar to Schizosaccharomyces pombe protein rds1 that may have a function in stress-related responses

Arch. IDVersionDate PublishedReview Level
1061535732024-11-18
curated
Arch. ID10615357
Version3
Date Published2024-11-18
Review Level
curated
Ferritin_2: Ferritin-like domainFerritin_2
PubMed:  8749363 | 9444766 | 3304136
SCOP:  3001658
CATH:  1.20.1260.10
Gene Ontology:  GO:0046872
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsferritin-like domain-containing proteinferritin-like domain-containing protein belongs to a broad superfamily of ferritin-like diiron-carboxylate proteins that catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; similar to Schizosaccharomyces pombe protein rds1 that may have a function in stress-related responses
Name, label and taxonomic scope
Tax. ExpAll organisms
Nameferritin-like domain-containing protein
Labelferritin-like domain-containing protein belongs to a broad superfamily of ferritin-like diiron-carboxylate proteins that catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; similar to Schizosaccharomyces pombe protein rds1 that may have a function in stress-related responses
Supporting evidence
Comments
  • The iron-free (apoferritin) ferritin molecule is a protein shell composed of 24 protein chains. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the dinuclear ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite; the protein shell can hold up to 4500 iron atoms.
CDD
  • pfam13668: Ferritin_2 : Ferritin-like domain
  • cd00657: Ferritin_like : Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Protein Accession
  • P53693: RecName: Full=Protein rds1
  • KXJ87306: ferritin-like domain-domain-containing protein [Microdochium bolleyi]
Publications
  • PMID 7565608: Schizosaccharomyces pombe rds1, an adenine-repressible gene regulated by glucose, ammonium, phosphate, carbon dioxide and temperature.
  • PMID 8749363: Di-iron-carboxylate proteins.
  • PMID 9444766: Structure-function relationships in the ferritins.
  • PMID 3304136: Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms.
Conserved domains in this architecture
AccessionShort nameTitle
pfam13668Ferritin_2Ferritin-like domain

    HHS Vulnerability Disclosure