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GNAT family N-acetyltransferase

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; also contains atypical SDR family oxidoreductase domain; similar to Myxococcus xanthus ActC

Arch. IDVersionDate PublishedReview Level
1039540312021-09-10
curated
Arch. ID10395403
Version1
Date Published2021-09-10
Review Level
curated
Rossmann-fold NAD(P)(+)-binding proteins: A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.Rossmann-fold NAD(P)(+)-binding proteinsAcetyltransf_1: Acetyltransferase (GNAT) familyAcetyltransf_1
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsGNAT family N-acetyltransferaseGNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; also contains atypical SDR family oxidoreductase domain; similar to Myxococcus xanthus ActC
Name, label and taxonomic scope
Tax. ExpAll organisms
NameGNAT family N-acetyltransferase
LabelGNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; also contains atypical SDR family oxidoreductase domain; similar to Myxococcus xanthus ActC
Supporting evidence
CDD
  • cd05266: SDR_a4 : atypical (a) SDRs, subgroup 4
  • pfam00583: Acetyltransf_1 : Acetyltransferase (GNAT) family
Publications
  • PMID 11359579: The act operon controls the level and time of C-signal production for Myxococcus xanthus development.
Protein Accession
  • AAK38651: ActC [Myxococcus xanthus DK 1622]
  • OCQ56843: GCN5 family acetyltransferase [Francisella tularensis]
Conserved domains in this architecture
AccessionShort nameTitle
cl21454Rossmann-fold NAD(P)(+)-binding proteinsA large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.
pfam00583Acetyltransf_1Acetyltransferase (GNAT) family

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