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serine/threonine protein kinase

serine/threonine protein kinase containing PASTA domains, similar to Bacillus subtilis PrkC and Mycobacterium PknB

Arch. IDVersionDate PublishedReview Level
1019599612016-05-13
curated
Arch. ID10195996
Version1
Date Published2016-05-13
Review Level
curated
STKc_PknB_like: Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteinsSTKc_PknB_likePASTA_pknB: PASTA domain of bacterial serine/threonine kinase pknB-like proteinsPASTA_pknBPASTA: PASTA domainPASTAPASTA_pknB: PASTA domain of bacterial serine/threonine kinase pknB-like proteinsPASTA_pknB
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsserine/threonine protein kinaseserine/threonine protein kinase containing PASTA domains, similar to Bacillus subtilis PrkC and Mycobacterium PknB
Name, label and taxonomic scope
Tax. ExpAll organisms
Nameserine/threonine protein kinase
Labelserine/threonine protein kinase containing PASTA domains, similar to Bacillus subtilis PrkC and Mycobacterium PknB
Supporting evidence
Comments
  • also known as protein phosphokinase; protein serine kinase;protein serine-threonine kinase;protein-serine kinase;serine kinase;serine protein kinase;serine(threonine) protein kinase; serine-specific protein kinase;serine/threonine protein kinase;threonine-specific protein kinase.
  • Mycobacterium PknB regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host.
  • Bacillus subtilis PrkC is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy.
E.C. Number
Protein Accession
  • P9WI81: RecName: Full=Serine/threonine-protein kinase PknB
  • O34507: RecName: Full=Serine/threonine-protein kinase PrkC; Short=Ser/Thr-protein kinase PrkC
CDD
Publications
  • PMID 18984160: A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments.
  • PMID 12406230: Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes.
  • PMID 20462494: The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation.
Conserved domains in this architecture
AccessionShort nameTitle
cd06577PASTA_pknBPASTA domain of bacterial serine/threonine kinase pknB-like proteins
cd14014STKc_PknB_likeCatalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
pfam03793PASTAPASTA domain
Functional sites in this architecture
TitleTypeSource domain
ATP binding sitechemical bindingcd14014
dimer interfacepolypeptide bindingcd14014
active siteactivecd14014
polypeptide substrate binding sitepolypeptide bindingcd14014
activation loop (A-loop)othercd14014

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