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nuclear hormone receptor family protein

nuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes

Arch. IDVersionDate PublishedReview Level
1016129622022-01-18
curated
Arch. ID10161296
Version2
Date Published2022-01-18
Review Level
curated
NR_DBD_HNF4A: DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingersNR_DBD_HNF4ANR_LBD: The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulatorsNR_LBD
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsnuclear hormone receptor family proteinnuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes
Name, label and taxonomic scope
Tax. ExpAll organisms
Namenuclear hormone receptor family protein
Labelnuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes
Supporting evidence
Protein Accession
  • NP_001040766: NR LBD domain-containing protein [Caenorhabditis elegans]
  • O45436: RecName: Full=Nuclear hormone receptor family member nhr-4
CDD
  • cd06960: NR_DBD_HNF4A : DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  • pfam00104: Hormone_recep : Ligand-binding domain of nuclear hormone receptor
Publications
  • PMID 15242336: The evolution of the nuclear receptor superfamily.
  • PMID 10022975: The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.
  • PMID 15983867: Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.
Gene IDs
Conserved domains in this architecture
AccessionShort nameTitle
cd06157NR_LBDThe ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
cd06960NR_DBD_HNF4ADNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
Functional sites in this architecture
TitleTypeSource domain
zinc binding siteion bindingcd06960
DNA binding sitenucleotide bindingcd06960
homodimer interfacepolypeptide bindingcd06960
ligand binding sitechemical bindingcd06157
coregulator recognition siteactivecd06157

    HHS Vulnerability Disclosure