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phosphatidate cytidylyltransferase

phosphatidate cytidylyltransferase catalyzes the reaction of CTP and phosphatidate to form diphosphate and CDP-diacylglycerol, a central liponucleotide for phospholipid biosynthesis

Arch. IDVersionDate PublishedReview Level
1000173342024-08-14
curated
Arch. ID10001733
Version4
Date Published2024-08-14
Review Level
curated
CdsA: CDP-diglyceride synthetase [Lipid transport and metabolism]CdsA
Gene Ontology:  GO:0004605 | GO:0016024
EC:  2.7.7.41
PubMed:  2995359
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsphosphatidate cytidylyltransferasephosphatidate cytidylyltransferase catalyzes the reaction of CTP and phosphatidate to form diphosphate and CDP-diacylglycerol, a central liponucleotide for phospholipid biosynthesis
Name, label and taxonomic scope
Tax. ExpAll organisms
Namephosphatidate cytidylyltransferase
Labelphosphatidate cytidylyltransferase catalyzes the reaction of CTP and phosphatidate to form diphosphate and CDP-diacylglycerol, a central liponucleotide for phospholipid biosynthesis
Supporting evidence
Comments
  • also known as CDP-diacylglycerol synthase; CDP-diglyceride diphosphorylase; CDP-diglyceride pyrophosphorylase; CDP-diglyceride synthetase.
E.C. Number
Protein Accession
  • O31752: RecName: Full=Phosphatidate cytidylyltransferase; AltName: Full=CDP-DAG synthase; AltName: Full=CDP-DG synthase; AltName: Full=CDP-diacylglycerol synthase; Short=CDS; AltName: Full=CDP-diglyceride pyrophosphorylase; AltName: Full=CDP-diglyceride synthase;
  • PJY16976: CDP-diglyceride synthetase, partial [Escherichia coli]
Gene IDs
CDD
Publications
  • PMID 15743965: Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
  • PMID 24968740: Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis.
  • PMID 2995358: Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli.
  • PMID 2995359: Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli.
Conserved domains in this architecture
AccessionShort nameTitle
COG0575CdsACDP-diglyceride synthetase [Lipid transport and metabolism]

    HHS Vulnerability Disclosure