9GYO: CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395

PDB ID: 9GYODownload
MMDB ID: 253438
PDB Deposition Date: 2024/10/2
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.5  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 9GYO: pentameric; determined by author
Molecular Components in 9GYO
Label Count Molecule
Proteins (5 molecules)
1
Isoform Gnas-2 of Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody 35
Molecule annotation
1
Soluble Cytochrome B562,g-protein Coupled Bile Acid Receptor 1
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
2
3
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303