9FMR: Structure of DDB1/Cdk12/Cyclin K with molecular glue SR-4835

PDB ID: 9FMRDownload
MMDB ID: 253763
PDB Deposition Date: 2024/6/7
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 3.9  Å
Source Organism:
Similar Structures:
Biological Unit for 9FMR: nonameric; determined by author and by software
Molecular Components in 9FMR
Label Count Molecule
Proteins (9 molecules)
3
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
3
Cyclin-dependent Kinase 12
(Gene symbol: CDK12)
Molecule annotation
3
Cyclin-k
(Gene symbol: CCNK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
3
~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303