9EQG: CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin

PDB ID: 9EQGDownload
MMDB ID: 252567
PDB Deposition Date: 2024/3/21
Updated in MMDB: 2024/09
Experimental Method:
electron microscopy
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 9EQG: pentameric; determined by author and by software
Molecular Components in 9EQG
Label Count Molecule
Proteins (5 molecules)
2
Gamma-aminobutyric Acid Receptor Subunit Alpha-1
(Gene symbol: GABRA1)
Molecule annotation
2
Gamma-aminobutyric Acid Receptor Subunit Beta-3
(Gene symbol: GABRB3)
Molecule annotation
1
Gamma-aminobutyric Acid Receptor Subunit Gamma-2
(Gene symbol: GABRG2)
Molecule annotation
Chemicals and Non-standard biopolymers (75 molecules)
1
13
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
6
beta-D-mannopyranosebeta-D-mannopyranose
3
16
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
5
11
DECANEDECANE
6
10
HEXANEHEXANE
7
2
[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate
8
5
HEXADECANEHEXADECANE
9
3
PALMITIC ACIDPALMITIC ACID
10
3
CHLORIDE IONCHLORIDE ION
11
2
GAMMA-AMINO-BUTANOIC ACIDGAMMA-AMINO-BUTANOIC ACID
12
1
DECANEDECANE
13
1
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303