9CMP: Structure of human Argonaute2-guide-target complex in a fully paired, slicing-competent conformation

PDB ID: 9CMPDownload
MMDB ID: 256547
PDB Deposition Date: 2024/7/15
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 9CMP: trimeric; determined by author
Molecular Components in 9CMP
Label Count Molecule
Protein (1 molecule)
1
Protein Argonaute-2
(Gene symbol: AGO2)
Molecule annotation
Nucleotides(2 molecules)
1
RNA (5'-r(p*up*gp*gp*ap*ap*gp*ap*cp*up*ap*gp*up*gp*ap*up*up*up*up*gp*up*u)-3')
Molecule annotation
1
RNA (5'-r(*cp*ap*ap*cp*ap*ap*ap*ap*up*cp*ap*cp*up*ap*gp*up*cp*up*up*cp*cp*a)-3')
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303