9CHO: Autoinhibited full-length LRRK2(I2020T) on microtubules with MLi-2

PDB ID: 9CHODownload
MMDB ID: 257300
PDB Deposition Date: 2024/7/1
Updated in MMDB: 2025/12
Experimental Method:
electron microscopy
Resolution: 7.8  Å
Source Organism:
Similar Structures:
Biological Unit for 9CHO: monomeric; determined by author
Molecular Components in 9CHO
Label Count Molecule
Protein (1 molecule)
1
Leucine-rich Repeat Serine/threonine-protein Kinase 2
(Gene symbol: LRRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
(2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine(2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303