9C87: Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX

PDB ID: 9C87Download
MMDB ID: 253698
PDB Deposition Date: 2024/6/12
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.7  Å
Source Organism:
Similar Structures:
Biological Unit for 9C87: 21-meric; determined by author
Molecular Components in 9C87
Label Count Molecule
Proteins (21 molecules)
6
Atp-dependent CLP Protease Atp-binding Subunit Clpx
Molecule annotation
1
Dihydrofolate Reductase
(Gene symbol: folA)
Molecule annotation
14
Atp-dependent CLP Protease Proteolytic Subunit
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
3
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
2
4
MAGNESIUM IONMAGNESIUM ION
3
3
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
4
1
METHOTREXATEMETHOTREXATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303