9C10: AMG 193, a clinical stage MTA-cooperative PRMT5 inhibitor, drives anti-tumor activity preclinically and in patients with MTAP-deleted cancers

PDB ID: 9C10Download
MMDB ID: 253098
PDB Deposition Date: 2024/5/28
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.85  Å
Source Organism:
Similar Structures:
Biological Unit for 9C10: dimeric; determined by author
Molecular Components in 9C10
Label Count Molecule
Proteins (2 molecules)
1
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
1
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
GLYCEROLGLYCEROL
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
1
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303