9B6H: Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3

PDB ID: 9B6HDownload
MMDB ID: 251355
PDB Deposition Date: 2024/3/25
Updated in MMDB: 2024/08
Experimental Method:
electron microscopy
Resolution: 2.76  Å
Source Organism:
Similar Structures:
Biological Unit for 9B6H: tetrameric; determined by author
Molecular Components in 9B6H
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily M Member 8
(Gene symbol: Trpm8)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
4
3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene
2
12
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
3
4
nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphanenonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane
4
4
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303