9AY7: Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF

PDB ID: 9AY7Download
MMDB ID: 245621
PDB Deposition Date: 2024/3/7
Updated in MMDB: 2024/07
Experimental Method:
x-ray diffraction
Resolution: 2.41  Å
Source Organism:
Similar Structures:
Biological Unit for 9AY7: dimeric; determined by author and by software (PISA)
Molecular Components in 9AY7
Label Count Molecule
Proteins (2 molecules)
1
RAF Proto-oncogene Serine/threonine-protein Kinase
(Gene symbol: RAF1)
Molecule annotation
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
NICKEL (II) IONNICKEL (II) ION
4
5
ACETATE IONACETATE ION
5
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303