9AXM: Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer

PDB ID: 9AXMDownload
MMDB ID: 245618
PDB Deposition Date: 2024/3/6
Updated in MMDB: 2024/07
Experimental Method:
x-ray diffraction
Resolution: 2.42  Å
Source Organism:
Similar Structures:
Biological Unit for 9AXM: tetrameric; determined by author
Molecular Components in 9AXM
Label Count Molecule
Proteins (4 molecules)
2
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol: MAP2K1)
Molecule annotation
2
Serine/threonine-protein Kinase A-raf
(Gene symbol: ARAF)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
Unknown
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
4
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
3
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303