9AXF: Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent

PDB ID: 9AXFDownload
MMDB ID: 245616
PDB Deposition Date: 2024/3/6
Updated in MMDB: 2024/05
Experimental Method:
electron microscopy
Resolution: 3.5  Å
Source Organism:
Mus musculus▼
Similar Structures:
Biological Unit for 9AXF: heptameric; determined by author
Molecular Components in 9AXF
Label Count Molecule
Proteins (7 molecules)
2
Extracellular Calcium-sensing Receptor
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1,adenylate Cyclase-stimulating G Alpha Protein
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Single-chain Antibody Fragment Scfv16
Molecule annotation
1
Nanobody Nb-35
Molecule annotation
Chemicals and Non-standard biopolymers (42 molecules)
1
16
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CYCLOMETHYLTRYPTOPHANCYCLOMETHYLTRYPTOPHAN
3
2
PHOSPHATE IONPHOSPHATE ION
4
7
CALCIUM IONCALCIUM ION
5
2
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
6
1
Lauryl Maltose Neopentyl GlycolLauryl Maltose Neopentyl Glycol
7
4
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
8
8
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303