9AVG: Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs

PDB ID: 9AVGDownload
MMDB ID: 245610
PDB Deposition Date: 2024/3/2
Updated in MMDB: 2024/05
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Similar Structures:
Biological Unit for 9AVG: pentameric; determined by author
Molecular Components in 9AVG
Label Count Molecule
Proteins (5 molecules)
2
Isoform 1 of Extracellular Calcium-sensing Receptor
(Gene symbol: CASR)
Molecule annotation
1
Chimeric Mini Guanine Nucleotide-binding Protein G(i)(s) Subunit Alpha
(Gene symbol: GNAI1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
13
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CYCLOMETHYLTRYPTOPHANCYCLOMETHYLTRYPTOPHAN
3
2
PHOSPHATE IONPHOSPHATE ION
4
6
CALCIUM IONCALCIUM ION
5
2
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
6
1
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
7
1
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303