8ZYJ: Cryo-EM structure of human testis-specific Na+,K+-ATPase alpha4 in ouabain-bound form

PDB ID: 8ZYJDownload
MMDB ID: 256058
PDB Deposition Date: 2024/6/18
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 2.37  Å
Source Organism:
Similar Structures:
Biological Unit for 8ZYJ: dimeric; determined by author and by software
Molecular Components in 8ZYJ
Label Count Molecule
Proteins (2 molecules)
1
Sodium/potassium-transporting Atpase Subunit Alpha-4
(Gene symbol: ATP1A4)
Molecule annotation
1
Sodium/potassium-transporting Atpase Subunit Beta-1
(Gene symbol: ATP1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
SODIUM IONSODIUM ION
3
1
CHOLESTEROLCHOLESTEROL
4
1
OUABAINOUABAIN
5
3
2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside
6
1
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
7
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303