8YW5: Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex

PDB ID: 8YW5Download
MMDB ID: 250846
PDB Deposition Date: 2024/3/29
Updated in MMDB: 2024/08
Experimental Method:
electron microscopy
Resolution: 2.84  Å
Source Organism:
synthetic construct▼
Similar Structures:
Molecular Components in 8YW5
Label Count Molecule
Proteins (6 molecules)
1
Retatrutide
Molecule annotation
1
Glucagon Receptor
Molecule annotation
1
Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody-35
Molecule annotation
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303