8XJJ: Co-crystal structure of SOS-1 and a potent, selective and orally bioavailable SOS1 inhibitor RGT-018

PDB ID: 8XJJDownload
MMDB ID: 251119
PDB Deposition Date: 2023/12/21
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8XJJ: monomeric; determined by author and by software
Molecular Components in 8XJJ
Label Count Molecule
Protein (1 molecule)
1
SON of Sevenless Homolog 1
(Gene symbol: SOS1)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
Unknown
2
12
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303