8XGJ: Human Cx36/GJD2 gap junction channel in complex with mefloquine

PDB ID: 8XGJDownload
MMDB ID: 254641
PDB Deposition Date: 2023/12/15
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 8XGJ: dodecameric; determined by author
Molecular Components in 8XGJ
Label Count Molecule
Proteins (12 molecules)
12
GAP Junction Delta-2 Protein
(Gene symbol: GJD2)
Molecule annotation
Chemicals and Non-standard biopolymers (96 molecules)
1
12
(11R,12S)- Mefloquine(11R,12S)- Mefloquine
2
84
1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303