8XFD: Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)

PDB ID: 8XFDDownload
MMDB ID: 247092
PDB Deposition Date: 2023/12/13
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8XFD: tetrameric; determined by author and by software
Molecular Components in 8XFD
Label Count Molecule
Proteins (4 molecules)
4
Isoform L-type of Pyruvate Kinase Pklr
(Gene symbol: PKLR)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
4
MAGNESIUM IONMAGNESIUM ION
2
4
1,6-di-O-phosphono-beta-D-fructofuranose1,6-di-O-phosphono-beta-D-fructofuranose
3
2
mitapivatmitapivat
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303