8XAR: Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 54

PDB ID: 8XARDownload
MMDB ID: 249000
PDB Deposition Date: 2023/12/5
Updated in MMDB: 2024/07
Experimental Method:
x-ray diffraction
Resolution: 1.19  Å
Source Organism:
Similar Structures:
Biological Unit for 8XAR: dimeric; determined by author
Molecular Components in 8XAR
Label Count Molecule
Proteins (2 molecules)
2
S-adenosylmethionine Synthase Isoform Type-2
(Gene symbol: MAT2A)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
2
7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one
2
2
GLYCEROLGLYCEROL
3
2
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
4
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303