8X7E: Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With JTE-151

PDB ID: 8X7EDownload
MMDB ID: 255709
PDB Deposition Date: 2023/11/24
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 8X7E: dimeric; determined by author and by software (PISA)
Molecular Components in 8X7E
Label Count Molecule
Proteins (2 molecules)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
1
Nuclear Receptor Corepressor 2
(Gene symbol: NCOR2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(4~{S})-6-[(2-chloranyl-4-methyl-phenyl)amino]-4-[4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]-1,2-oxazol-3-yl]-6-oxidanylidene-hexanoic acid(4~{S})-6-[(2-chloranyl-4-methyl-phenyl)amino]-4-[4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]-1,2-oxazol-3-yl]-6-oxidanylidene-hexanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303