8X7A: Treprostinil bound Prostacyclin Receptor G protein complex

PDB ID: 8X7ADownload
MMDB ID: 243845
PDB Deposition Date: 2023/11/23
Updated in MMDB: 2024/03
Experimental Method:
electron microscopy
Resolution: 2.56  Å
Source Organism:
Similar Structures:
Biological Unit for 8X7A: pentameric; determined by author and by software
Molecular Components in 8X7A
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short,gnas Complex Locus
(Gene symbol: GNAS)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
1
Nanobody35
Molecule annotation
1
Prostacyclin Receptor
(Gene symbol: PTGIR)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303