8WY3: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21

PDB ID: 8WY3Download
MMDB ID: 241848
PDB Deposition Date: 2023/10/30
Updated in MMDB: 2024/02
Experimental Method:
x-ray diffraction
Resolution: 2.78  Å
Source Organism:
Similar Structures:
Biological Unit for 8WY3: trimeric; determined by author
Molecular Components in 8WY3
Label Count Molecule
Proteins (3 molecules)
3
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
3
~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303