8WPU: Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein

PDB ID: 8WPUDownload
MMDB ID: 238948
PDB Deposition Date: 2023/10/10
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 8WPU: hexameric; determined by author and by software
Molecular Components in 8WPU
Label Count Molecule
Proteins (6 molecules)
2
Extracellular Calcium-sensing Receptor,calcium-sensing Receptor
Molecule annotation
1
G Subunit Q (Gi2-mini-gq Chimeric)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Scfv16
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
13
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amineN-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
3
2
TRYPTOPHANTRYPTOPHAN
4
4
CALCIUM IONCALCIUM ION
5
2
PHOSPHATE IONPHOSPHATE ION
6
1
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303