8WMU: Structural basis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents with dual-binding sites

PDB ID: 8WMUDownload
MMDB ID: 253276
PDB Deposition Date: 2023/10/4
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 8WMU: hexameric; determined by author
Molecular Components in 8WMU
Label Count Molecule
Proteins (6 molecules)
2
Detyrosinated Tubulin Alpha-1b Chain
Molecule annotation
2
Tubulin Beta Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
1
Tubulin--tyrosine Ligase
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
3
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
3
MAGNESIUM IONMAGNESIUM ION
3
2
CALCIUM IONCALCIUM ION
4
1
GLYCEROLGLYCEROL
5
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
6
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
7
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
8
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
9
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
10
1
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303